Host and Parasite (part1, part2)
Year part1 : September, 1973
part2 : August, 1975
Time part1 : 34 min
part2 : 30 min
Summary What is the relationship between the normal flora of the intestinal tract and a host? To address this question, we investigated and succeeded to film the movement of intestinal villi and effects of nonpathogenic and pathogenic bacteria on the host organs. For the first time in the world, we discovered and recorded the spontaneous movement of villi under a microscope by a time lapse-filming technique. This movement was accelerated by an addition of lactic acid bacteria, which are part of the intestinal normal flora. On the other hand, pathogenic bacteria caused severe damages to the intestinal mucosa of mice: Vibrio cholerae induced agglutination of the vessels of the villi, pathogenic Escherichia coli explosively destroyed the tissue, and Salmonella caused remarkable phenomena i.e. the vessels of the villi involuted and finally vanished even though the blood flow continued. This event started slower in germ-free mice than in normal animals. However, once this change started, the damages advanced twice as fast in the former as in the latter. These phenomena are seen in the "Host and Parasite, part 1."

In 1970's Japan, little studies have reported about the relationship between intestinal flora and intestinal tissue of host in. From this study, we continued further examination with scientists.

After two years, in the "Host and Parasite, part 2", the biological meaning of the movement of intestinal villi and the characteristic vanishing of the vessels caused by Salmonella infections are dealt with. Time lapse filming demonstrated that substances accumulating in the villi are forwarded to the lymph duct by contractions of the villi. Molecular mechanism of contractions of villi seems apparently distinct from that of the muscle, and still remains unknown. The vanishing of vessels from intestinal villi caused by Salmonella is not a postmortem change. Salmonella caused edema in tip cells of villi, and thereafter the cells were detached. The experiment with germ free nude mice suggested that the effect of bacteria could be mediated by immune responses.

These films were invited for special screening at Cholera meetings in Japan and USA Medical Conferences.
Awards part1
1973
The Silver Bacuranium, First Prize in the 18th International Scientific and Educational Film Festival at Padova University in the 34th Venice International Film Festival, ITALY
1974
Award in the category of Educational Film / Biology, Chemistry, XIV Mostra International do Filme Cientifico, Rio de Janeiro, BRAJIL
日本医師会推薦
（前編）
1973　ベニス・パドバ国際科学・教育映画祭生理学部門第一位賞
1974　リオ・デ・ジャネイロ国際科学映画祭金賞
日本医師会推薦
part2
1975　日米医学協力計画コレラ専門会議特別参加
1976　国際科学技術映画コンクール東京大会銅賞
Planning Miyarisan Pharmaceutical Co.,Ltd.
Miyairi Kinzai Kenkyujo Co.,Ltd.
  ※The name of a planning company, supervisor and their title is that at the time of completion.
Staff part1
Director : Takeda, Junichiro
Screenplay : Takeda, Junichiro
Cinematographer : Hasegawa, Takahisa
Experiments : Asaka, Tokio
Music : Ikeno, Sei
Narrator : Kawakubo, Kiyoshi
Production Manager : Gunji, Ryo
Producer : Hayashi, Rokuro
part2
Director : Takeda, Junichiro
Cinematographer : Hasegawa, Takahisa / Uehara, Takeshi
Experiments : Asaka, Tokio
Music : Ikeno, Sei
Narrator : Kawakubo, Kiyoshi
Producer : Hayashi, Rokuro